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Comparison of Simoa(TM) and Ella(TM) to assess serum neurofilament-light chain in multiple sclerosis

Audrey Gauthier 1 Sébastien Viel 2, 3 Magali Perret 3 Guillaume Brocard 4, 3, 5 Romain Casey 4, 3, 5 Christine Lombard 3 Sabine Laurent-Chabalier 6 Marc Debouverie 7, 8 Gilles Edan 9, 10 Sandra Vukusic 4, 3, 5 Christine Lebrun-Frenay 11 Jerome de Seze 12 David Axel Laplaud 13, 14 Giovanni Castelnovo 6 Olivier Gout 15 Aurélie Ruet 16, 17, 18 Thibault Moreau 19 Olivier Casez 20 Pierre Clavelou 21, 22 Eric Berger 23 Helene Zephir 24 Sophie Trouillet-Assant 2, 3 Eric Thouvenot 6, 25, * 
Abstract : We compared Simoa and Ella immunoassays to assess serum neurofilament-light chain levels in 203 multiple sclerosis patients from the OFSEP HD study. There was a strong correlation (ρ = 0.86, p < 0.0001) between both platforms. The Ella instrument overestimated values by 17%, but as the data were linear (p = 0.57), it was possible to apply a correction factor to Ella results. As for Simoa , serum neurofilament-light chain levels measured by Ella were correlated with age and EDSS and were significantly higher in active multiple sclerosis, suggesting that these assays are equivalent and can be used in routine clinical practice.
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https://hal.archives-ouvertes.fr/hal-03216866
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Tuesday, May 31, 2022 - 12:11:15 PM
Last modification on : Wednesday, September 28, 2022 - 4:20:11 PM

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Ann Clin Transl Neurol - 2021 ...
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Audrey Gauthier, Sébastien Viel, Magali Perret, Guillaume Brocard, Romain Casey, et al.. Comparison of Simoa(TM) and Ella(TM) to assess serum neurofilament-light chain in multiple sclerosis. Annals of Clinical and Translational Neurology, Wiley, 2021, 8 (5), pp.1141-1150. ⟨10.1002/acn3.51355⟩. ⟨hal-03216866⟩

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