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Modelling irradiation by EM waves of multifunctionalized iron oxide nanoparticles and subsequent drug release

Abstract : Thermal transport in the environment close to the periphery of the nanoparticle, from a few angstroms to less than a nanometer scale, is becoming increasingly important with the advent of several biomedical applications of multifunctional magnetic nanoparticles, including drug delivery, magnetic resonance imaging, and hyperthermia therapy. We present a multiscale and multiphysics model of the irradiation by electromagnetic waves of radiofrequency of iron oxide nanoparticles functionalized by drug-releasing polymers used as new multifunctional therapeutic compounds against tumors. We compute ab initio the thermal conductivity of the polymer chains as a function of the length, model the unfolding of the polymer after heat transfer from the nanoparticle by molecular mechanics, and develop a multiscale thermodynamic and heat transfer model including the surrounding medium (water) in order to model the drug release.
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https://hal-univ-lemans.archives-ouvertes.fr/hal-01905415
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Soumis le : jeudi 25 octobre 2018 - 17:23:20
Dernière modification le : mardi 14 décembre 2021 - 10:26:03

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Feng Wang, Florent Calvayrac, V. Montembault, Laurent Fontaine. Modelling irradiation by EM waves of multifunctionalized iron oxide nanoparticles and subsequent drug release. Journal of Physics: Conference Series, IOP Publishing, 2015, 633, ⟨10.1088/1742-6596/633/1/012003⟩. ⟨hal-01905415⟩

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