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Modelling irradiation by EM waves of multifunctionalized iron oxide nanoparticles and subsequent drug release
Abstract : Thermal transport in the environment close to the periphery of the nanoparticle, from a few angstroms to less than a nanometer scale, is becoming increasingly important with the advent of several biomedical applications of multifunctional magnetic nanoparticles, including drug delivery, magnetic resonance imaging, and hyperthermia therapy. We present a multiscale and multiphysics model of the irradiation by electromagnetic waves of radiofrequency of iron oxide nanoparticles functionalized by drug-releasing polymers used as new multifunctional therapeutic compounds against tumors. We compute ab initio the thermal conductivity of the polymer chains as a function of the length, model the unfolding of the polymer after heat transfer from the nanoparticle by molecular mechanics, and develop a multiscale thermodynamic and heat transfer model including the surrounding medium (water) in order to model the drug release.
https://hal-univ-lemans.archives-ouvertes.fr/hal-01905415
Contributeur : Laurent Fontaine Connectez-vous pour contacter le contributeur
Soumis le : jeudi 25 octobre 2018 - 17:23:20
Dernière modification le : mardi 14 décembre 2021 - 10:26:03
Contributeur : Laurent Fontaine Connectez-vous pour contacter le contributeur
Soumis le : jeudi 25 octobre 2018 - 17:23:20
Dernière modification le : mardi 14 décembre 2021 - 10:26:03
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