Synthesis of poly(oxyethylene phosphate)-g-poly(ethylene oxide) via the “grafting onto” approach by “click” chemistry

Abstract : A general method for the synthesis of grafted poly(alkylene phosphate)s is presented by combination of Atherton–Todd reaction and “click” chemistry. In the first step, the proposed method uses in a first step the Atherton-–Todd reaction to yield poly(tetraoxyethylene phosphate) with pendant acetylenic groups from poly(tetraoxyethylene H-phosphonate). In a the second step, “click” functionalization of the acetylene-containing poly(tetraoxyethylene phosphate) with azido-terminated poly(ethylene oxide)PEO leads to poly(tetraoxyethylene phosphate)-g-poly(ethylene oxide).