Abstract : For several years, lipids and especially n − 3 and n − 6 polyunsaturated fatty acids (PUFAs) receive much attention in human health. Epidemiological studies tend to correlate a PUFA-rich diet with a reduced incidence of cancer, including breast cancer. However, the molecular and cellular mechanisms supporting the effect of PUFAs in breast cancer cells remain relatively unknown. Here, we review some recent progress in understanding the impact that PUFA may have on breast cancer cell proliferation, apoptosis, migration, and invasion. While most of the results obtained with docosahexaenoic acid and/or eicosapentaenoic acid show a decrease of tumor cell proliferation and/or aggressivity, there is some evidence that other lipids, which accumulate in breast cancer tissues, such as arachidonic acid may have opposite effects. Finally, lipids and especially PUFAs appear as potential adjuvants to conventional cancer therapy.
https://hal-univ-lemans.archives-ouvertes.fr/hal-01906252 Contributeur : Benoît ChénaisConnectez-vous pour contacter le contributeur Soumis le : vendredi 4 mars 2022 - 17:56:49 Dernière modification le : mercredi 27 avril 2022 - 03:58:57 Archivage à long terme le : : dimanche 5 juin 2022 - 19:33:54
Benoît Chénais, Vincent Blanckaert. The Janus Face of Lipids in Human Breast Cancer: How Polyunsaturated Fatty Acids Affect Tumor Cell Hallmarks. International Journal of Breast Cancer, Hindawi, 2012, 2012, pp.712536. ⟨10.1155/2012/712536⟩. ⟨hal-01906252⟩