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Article dans une revue
Docosahexaenoic acid intake decreases proliferation, increases apoptosis and decreases the invasive potential of the human breast carcinoma cell line MDA-MB-231
Abstract : Breast cancer is the most common cancer in women in industrialized countries. Environmental factors, such as differences in diet are likely to have an important influence on cancer emergence. Among these factors, n-3 polyunsaturated-fatty acids, such as docosahexaenoic acid (DHA), are good candidates for preventing breast cancer. Here we investigate the effect of DHA on the human breast cancer cell line MDA-MB-231 and show that DHA incorpo- ration i) has an anti-proliferative effect, ii) induces apoptosis via a transient increase in caspase-3 activity and the promotion of nuclear condensation, and iii) reduces the invasive potential of MDA-MB-231 cells. To conclude, DHA may have beneficial effects as a result of slowing the proliferation of tumor cells, and minimizing their metastatic potential.
https://hal-univ-lemans.archives-ouvertes.fr/hal-02001122
Contributeur : Lionel Ulmann Connectez-vous pour contacter le contributeur
Soumis le : jeudi 31 janvier 2019 - 10:13:11
Dernière modification le : mardi 28 septembre 2021 - 16:38:04
Contributeur : Lionel Ulmann Connectez-vous pour contacter le contributeur
Soumis le : jeudi 31 janvier 2019 - 10:13:11
Dernière modification le : mardi 28 septembre 2021 - 16:38:04