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The effect of dietary α-bromopalmitate on blood lipids in the rat

Tor-Arne Hagve 1, 2 Michel Narce 3 Morten Grønn 1 Erik Christensen 1 Lionel Ulmann 3, * Jean Pierre Poisson 3 Bjørn Christophersen 1
* Auteur correspondant
1 Institute of Clinical Biochemistry [Oslo, Norway]
2 Department of Physiological Chemistry [Columbus, OH, USA]
3 Faculté des Sciences Mirandes - Laboratoire de Physiologie Animale et de la Nutrition [Dijon]
Abstract : When alpha-bromopalmitate was fed to rats for 9-30 days, the level of serum triacylglycerol increased up to 2-fold over the concentration of controls. alpha-Bromopalmitate treatment had no effect on concentration of complex lipids in liver, while the triacylglycerol level in heart was significantly enhanced. From metabolic studies using isolated hepatocytes and liver microsomes, it is suggested that the increased serum triacylglycerol level after alpha-bromopalmitate feeding is mainly due to reduced fatty acid oxidation in both liver and peripheral tissues, and to a lesser extent, to inhibited fatty acid uptake and esterification.
Keywords : Cholesterol Triacylglycerol Fatty acid Fatty acid binding protein (Rat serum) alpha-Bromopalmitate
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https://hal-univ-lemans.archives-ouvertes.fr/hal-02303594
Contributeur : Lionel Ulmann <>
Soumis le : mercredi 2 octobre 2019 - 14:16:26
Dernière modification le : mercredi 9 octobre 2019 - 01:36:09

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Tor-Arne Hagve, Michel Narce, Morten Grønn, Erik Christensen, Lionel Ulmann, et al.. The effect of dietary α-bromopalmitate on blood lipids in the rat. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Elsevier, 1989, 1004 (1), pp.143-146. ⟨10.1016/0005-2760(89)90225-7⟩. ⟨hal-02303594⟩

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