The effect of dietary α-bromopalmitate on blood lipids in the rat

Tor-Arne Hagve (1, 2) , Michel Narce (3) , Morten Grønn (1) , Erik Christensen (1) , Lionel Ulmann (3) , Jean Pierre Poisson (3) , Bjørn Christophersen (1)

1 Institute of Clinical Biochemistry [Oslo, Norway]
2 Department of Physiological Chemistry [Columbus, OH, USA]
3 ENSBANA - Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon

When alpha-bromopalmitate was fed to rats for 9-30 days, the level of serum triacylglycerol increased up to 2-fold over the concentration of controls. alpha-Bromopalmitate treatment had no effect on concentration of complex lipids in liver, while the triacylglycerol level in heart was significantly enhanced. From metabolic studies using isolated hepatocytes and liver microsomes, it is suggested that the increased serum triacylglycerol level after alpha-bromopalmitate feeding is mainly due to reduced fatty acid oxidation in both liver and peripheral tissues, and to a lesser extent, to inhibited fatty acid uptake and esterification.

Mots clés: Fatty acid binding protein; (Rat serum); alpha-Bromopalmitate; Fatty acid; Triacylglycerol; Cholesterol

Domaines: Cancer; Biochimie [q-bio.BM]; Alimentation et Nutrition

Tor-Arne Hagve, Michel Narce, Morten Grønn, Erik Christensen, Lionel Ulmann, et al.. The effect of dietary α-bromopalmitate on blood lipids in the rat. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1989, 1004 (1), pp.143-146. ⟨10.1016/0005-2760(89)90225-7⟩. ⟨hal-02303594⟩