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Article dans une revue
A Practical and Cost-Effective Method for the Synthesis of Bicyclo[2.2.2]octane-1,4-dicarboxylic Acid
Abstract : A short and efficient synthesis of bicyclo[2.2.2]octane-1,4-dicarboxylic acid involving the formation of a semicarbazone is developed, and a reproducible protocol for the reduction of this semicarbazone is described. The use of microwaves significantly shortens the duration of the sequence to the diacid compared to the previously described synthetic method. In addition, by shifting from the use of large amounts of Raney nickel to a solid-phase process, both the safety and cost are improved notably.
https://hal-univ-lemans.archives-ouvertes.fr/hal-02313642
Contributeur : Arnaud Martel Connectez-vous pour contacter le contributeur
Soumis le : vendredi 11 octobre 2019 - 14:18:27
Dernière modification le : mardi 14 décembre 2021 - 10:26:03
Contributeur : Arnaud Martel Connectez-vous pour contacter le contributeur
Soumis le : vendredi 11 octobre 2019 - 14:18:27
Dernière modification le : mardi 14 décembre 2021 - 10:26:03