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Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors

Abstract : Cyanobacteria (blue-green microalgae) are ubiquitous, Gram-negative photoautotrophic prokaryotes. They are considered as one of the most efficient sources of bioactive secondary metabo- lites. More than 50% of cyanobacteria are cultivated on commercial platforms to extract bioactive compounds, which have bene shown to possess anticancer activity. The chemically diverse natural compounds or their analogues induce cytotoxicity and potentially kill a variety of cancer cells via the induction of apoptosis, or altering the activation of cell signaling, involving especially the protein kinase-C family members, cell cycle arrest, mitochondrial dysfunctions and oxidative damage. These therapeutic properties enable their use in the pharma and healthcare sectors for the betterment of future generations. This review provides a baseline overview of the anti-cancerous cyanobacterial bioactive compounds, along with recently introduced nanomaterials that could be used for the development of new anticancer drugs to build a healthy future for mankind.
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https://hal-univ-lemans.archives-ouvertes.fr/hal-03106367
Contributeur : Benoît Chénais <>
Soumis le : lundi 11 janvier 2021 - 17:38:50
Dernière modification le : mercredi 13 janvier 2021 - 03:15:51

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Hina Qamar, Kashif Hussain, Aishwarya Soni, Anish Khan, Touseef Hussain, et al.. Cyanobacteria as Natural Therapeutics and Pharmaceutical Potential: Role in Antitumor Activity and as Nanovectors. Molecules, MDPI, 2021, 26, ⟨10.3390/molecules26010247⟩. ⟨hal-03106367⟩

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