Arrêt de service programmé du vendredi 10 juin 16h jusqu’au lundi 13 juin 9h. Pour en savoir plus
Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

Transposable Elements and Human Diseases: Mechanisms and Implication in the Response to Environmental Pollutants

Abstract : Transposable elements (TEs) are recognized as major players in genome plasticity and evolution. The high abundance of TEs in the human genome, especially the Alu and Long Interspersed Nuclear Element-1 (LINE-1) repeats, makes them responsible for the molecular origin of several diseases. This involves several molecular mechanisms that are presented in this review: insertional mutation, DNA recombination and chromosomal rearrangements, modification of gene expression, as well as alteration of epigenetic regulations. This literature review also presents some of the more recent and/or more classical examples of human diseases in which TEs are involved. Whether through insertion of LINE-1 or Alu elements that cause chromosomal rearrangements, or through epigenetic modifications, TEs are widely implicated in the origin of human cancers. Many other human diseases can have a molecular origin in TE-mediated chromosomal recombination or alteration of gene structure and/or expression. These diseases are very diverse and include hemoglobinopathies, metabolic and neurological diseases, and common diseases. Moreover, TEs can also have an impact on aging. Finally, the exposure of individuals to stresses and environmental contaminants seems to have a non-negligible impact on the epigenetic derepression and mobility of TEs, which can lead to the development of diseases. Thus, improving our knowledge of TEs may lead to new potential diagnostic markers of diseases.
Liste complète des métadonnées

https://hal-univ-lemans.archives-ouvertes.fr/hal-03598300
Contributeur : Benoît Chénais Connectez-vous pour contacter le contributeur
Soumis le : vendredi 4 mars 2022 - 18:10:02
Dernière modification le : jeudi 19 mai 2022 - 03:45:43

Fichier

Chénais_2022_IJMS.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

Citation

Benoît Chénais. Transposable Elements and Human Diseases: Mechanisms and Implication in the Response to Environmental Pollutants. International Journal of Molecular Sciences, MDPI, 2022, 23 (5), pp.2551. ⟨10.3390/ijms23052551⟩. ⟨hal-03598300⟩

Partager

Métriques

Consultations de la notice

7

Téléchargements de fichiers

2