Extracts from Wallis Sponges Inhibit Vibrio harveyi Biofilm Formation

Flore Caudal (1, 2) , Sophie Rodrigues (2) , Alain Dufour (2) , Sébastien Artigaud (1) , Gwenaelle Le Blay (1) , Sylvain Petek (1) , Alexis Bazire (2)

1 LEMAR - Laboratoire des Sciences de l'Environnement Marin (LEMAR)
2 LBCM - Laboratoire de Biotechnologie et Chimie Marines

Pathogenic bacteria and their biofilms are involved in many human and animal diseases and are a major public health problem with, among other things, the development of antibiotic resistance. These biofilms are known to induce chronic infections for which classical treatments using antibiotic therapy are often ineffective. Sponges are sessile filter-feeding marine organisms known for their dynamic symbiotic partnerships with diverse microorganisms and their production of numerous metabolites of interest. In this study, we investigated the antibiofilm efficacy of different extracts from sponges, isolated in Wallis, without biocidal activity. Out of the 47 tested extracts, from 28 different genera, 11 showed a strong activity against Vibrio harveyi biofilm formation. Moreover, one of these extracts also inhibited two quorum-sensing pathways of V. harveyi.

Mots clés: anti-biofilm activity; biofilm; marine natural products; sponge extract; Vibrio harveyi

Domaines: Sciences du Vivant [q-bio]

Flore Caudal, Sophie Rodrigues, Alain Dufour, Sébastien Artigaud, Gwenaelle Le Blay, et al.. Extracts from Wallis Sponges Inhibit Vibrio harveyi Biofilm Formation. Microorganisms, 2023, 11 (7), pp.1762. ⟨10.3390/microorganisms11071762⟩. ⟨hal-04155861⟩